3ADP 3Pi NADH H 1/2O2 ----> 3 ATP NADh H20

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1)acetyl coA combines with oxaloacetate to form citrate.

2)citrate then converts into isocitrate, water molecule is removed then added.

3)isocitrate is oxidized then releases CO2. NADH+ is reduced to NADH(caused by isocitrate dehydrogenase)

4)ketogluterate is oxidized, NAD+ is reduced to NADH which releases CO2. Then, it picks up coenzyme A to form succinly coA(ketogluterate dehydrogenase)

5)coA of succnyl coA is replaced by a phosphate group. ADP to ATP. Succinate is produced.

6)succinate oxidizes and forms fumerate. 2 H atoms are transferred to FAD which makes FADH2. Its electrons go to the electron transport chain.

7)water is added to fumerate, then turns into malate

8)malate oxidizes which regenerates oxaloacetate. NAD+ is reduced to NADH once again, ATP is produced.

TCA cycle is regulated mainly by concentration of ATP and NADH.


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