Red spots + cushing syndrome
Classified in Biology
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***Hyperadrenalism:
Hypercorticosolism (CUSHING Syndrome) | Hyperaldosteronism |
-Cortisol-Secreting Adrenal Neoplasia -ACTH-Secreting ectopic Tumor -ACTH-Secreting Put Adenoma(cushing disease) |
**Cushing Syndrome: |
^^CF: -sudden weight Gain - Truncal obesity -Buffalo hump -Moon Face -Abdominal Strai -Red Face Because BV become thinner clsoer to surface -Hypertension -Lab : Hypernitermeia, hypokalemia, Glucosuria |
^^Dx: 1-Low-Dose Dexamthasone Suppresion Test (1 mg of dexamethasone @ 12 ... In the morning Dexamethsone hsould suppres ACTH and cortisol production = >120 mg (In Cushing Cortisol Remains elevated) min (10:20-11:30 ) 2-Find out where if we have Pituitary Adenoma will be if there is Suppresion of Cortisol in dexamethasone Suppresion Test ! 3- If there is No Response to Dexamthasone Test (-), CORTISOL Still High ----> ACTH Secreting Tumour or Adrenal Neoplasia 4- Adrenal NEoplasia vs ACTH secreting Tumour: i-(ACTH Normal) ----------ACTH( High) |
**COnn Syndrome: -Excess Secretion of Aldosteorne From the adrenal Glannd, -Ussual Cause Is Adenoma ( |
^Sx: -Hypertension -Weakness -Fatigue -polyuria -polydipsia -Headahce -Lab : hypernitremia, Hypokaemia |
^Dx: -Aldosterone-To-Renin Ratio: 1-ARR >23.6 ------>primary Hyperaldosteronism -Abdominal CT -Lab: Hypernitremia & hypokalemia |
^^Tx: -Spiironolactone -Removed adrnel Gland , Adrenalectomy |
***Addison Syndrome: |
^^Gx -Loss of Cortisol ,hypocortislism -Cause = ? Or autoimmune -Acute Adrenal Insuff |
^^Sx: -Salt Craving -Orthostatic Hypotension -weakness -weight loss -Increase skin pigmentation -Amenorhea -BP slightly Lower -Lab: 1-Hyponatremia & Hyperkalemia 2-Metabolic Acidocis |
^^Dx: -Stablizing he PAtient -Cosynotropin Stimulation Test |
^^Tx: -better preventive ,keep patient out of adrenal crises -Replace GCD(cortisol ) and Minercorticoid(aldosterone) -to replace Minerlo we use Flurocortisone -increase predinosone if they becomes ill |